Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway
Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C Key Rings (PLC)-catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).Within the vasculature, TRPC channel ROCs contribute to smo